Drug interactions
Repaglinide + Sotagliflozin
Severity: Moderate
Repaglinide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers glucose, and with repaglinide it increases the risk of hypoglycemia.
What this interaction means in plain words
Repaglinide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT inhibition and insulin secretion stimulation.
What to do
Consider reducing the repaglinide dose when starting sotagliflozin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Repaglinide with Sotagliflozin?
MediHelp rates the interaction as moderate. Repaglinide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers glucose, and with repaglinide it increases the risk of hypoglycemia.
How serious is the interaction between Repaglinide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the repaglinide dose when starting sotagliflozin and monitor blood glucose.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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