Drug interactions
Repaglinide + Teclistamab
Severity: Moderate
Repaglinide and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab triggers cytokine release that can transiently suppress CYP enzyme activity. Repaglinide exposure may rise and cause hypoglycemia, mainly after the initial doses.
What this interaction means in plain words
Repaglinide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 and CYP2C8 reduces repaglinide metabolism.
What to do
Monitor blood glucose during step-up dosing and in the days after, especially during cytokine release syndrome. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Repaglinide with Teclistamab?
MediHelp rates the interaction as moderate. Repaglinide and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab triggers cytokine release that can transiently suppress CYP enzyme activity. Repaglinide exposure may rise and cause hypoglycemia, mainly after the initial doses.
How serious is the interaction between Repaglinide and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during step-up dosing and in the days after, especially during cytokine release syndrome. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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