Drug interactions
Repaglinide + Teriflunomide
Severity: Moderate
Repaglinide and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is metabolized by CYP2C8 and CYP3A4. Teriflunomide has been shown to increase repaglinide exposure, raising the risk of hypoglycemia.
What this interaction means in plain words
Repaglinide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 by teriflunomide reduces repaglinide clearance.
What to do
Monitor blood glucose and lower the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Teriflunomide?
MediHelp rates the interaction as moderate. Repaglinide and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is metabolized by CYP2C8 and CYP3A4. Teriflunomide has been shown to increase repaglinide exposure, raising the risk of hypoglycemia.
How serious is the interaction between Repaglinide and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and lower the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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