Drug interactions
Repaglinide + Tucatinib
Severity: Moderate
Repaglinide and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can raise repaglinide exposure. Higher repaglinide levels increase the risk of prolonged or severe hypoglycemia.
What this interaction means in plain words
Repaglinide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing part of repaglinide's oxidative metabolism (CYP2C8 is its main route).
What to do
Monitor blood glucose closely when starting or stopping tucatinib and reduce the repaglinide dose if hypoglycemia occurs. Consider an alternative antidiabetic agent if glucose control becomes unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Repaglinide with Tucatinib?
MediHelp rates the interaction as moderate. Repaglinide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can raise repaglinide exposure. Higher repaglinide levels increase the risk of prolonged or severe hypoglycemia.
How serious is the interaction between Repaglinide and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping tucatinib and reduce the repaglinide dose if hypoglycemia occurs. Consider an alternative antidiabetic agent if glucose control becomes unstable.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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