Drug interactions
Repotrectinib + Ribociclib
Severity: Major
Repotrectinib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase repotrectinib concentrations, raising the risk of its CNS effects such as dizziness and ataxia, as well as hepatotoxicity. Repotrectinib labeling advises avoiding strong and moderate CYP3A inhibitors.
What this interaction means in plain words
Repotrectinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Repotrectinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of repotrectinib by ribociclib.
What to do
Avoid the combination; if it cannot be avoided, monitor closely for neurologic and hepatic toxicity and consider repotrectinib dose adjustment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Repotrectinib with Ribociclib?
MediHelp rates the interaction as major. Repotrectinib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib inhibits CYP3A4 and may increase repotrectinib concentrations, raising the risk of its CNS effects such as dizziness and ataxia, as well as hepatotoxicity. Repotrectinib labeling advises avoiding strong and moderate CYP3A inhibitors.
How serious is the interaction between Repotrectinib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if it cannot be avoided, monitor closely for neurologic and hepatic toxicity and consider repotrectinib dose adjustment.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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