Drug interactions
Ribociclib + Rucaparib
Severity: Minor
Ribociclib and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 in vitro and clinically, and ribociclib is a CYP3A4 substrate. Ribociclib exposure may rise slightly, which could add to QT prolongation and neutropenia. The effect is expected to be modest.
What this interaction means in plain words
Ribociclib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated ribociclib metabolism by rucaparib.
What to do
No empirical dose change is needed. Monitor ECG, electrolytes and blood counts as already required for ribociclib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ribociclib with Rucaparib?
MediHelp rates the interaction as minor. Ribociclib and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 in vitro and clinically, and ribociclib is a CYP3A4 substrate. Ribociclib exposure may rise slightly, which could add to QT prolongation and neutropenia. The effect is expected to be modest.
How serious is the interaction between Ribociclib and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor ECG, electrolytes and blood counts as already required for ribociclib.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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