Drug interactions
Ribociclib + Ruxolitinib
Severity: Moderate
Ribociclib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise ruxolitinib exposure. This can increase cytopenias, particularly thrombocytopenia and neutropenia, which ribociclib can also cause.
What this interaction means in plain words
Ribociclib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing ruxolitinib metabolism.
What to do
Monitor complete blood counts frequently and adjust the ruxolitinib dose per labeling if cytopenias occur. Also monitor QTc given ribociclib's effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Ruxolitinib?
MediHelp rates the interaction as moderate. Ribociclib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise ruxolitinib exposure. This can increase cytopenias, particularly thrombocytopenia and neutropenia, which ribociclib can also cause.
How serious is the interaction between Ribociclib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust the ruxolitinib dose per labeling if cytopenias occur. Also monitor QTc given ribociclib's effect.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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