Drug interactions
Ribociclib + Stiripentol
Severity: Moderate
Ribociclib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4, so ribociclib exposure could change unpredictably. Reduced exposure could lessen ribociclib efficacy, while increased exposure could worsen QT prolongation and neutropenia. Ribociclib may also modestly raise stiripentol levels.
What this interaction means in plain words
Ribociclib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol, plus CYP3A4 inhibition by ribociclib.
What to do
Monitor ECG, electrolytes, blood counts and treatment response. Adjust ribociclib dose for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ribociclib and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Ribociclib with Stiripentol?
MediHelp rates the interaction as moderate. Ribociclib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4, so ribociclib exposure could change unpredictably. Reduced exposure could lessen ribociclib efficacy, while increased exposure could worsen QT prolongation and neutropenia. Ribociclib may also modestly raise stiripentol levels.
How serious is the interaction between Ribociclib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes, blood counts and treatment response. Adjust ribociclib dose for toxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
