Drug interactions
Ribociclib + Tramadol
Severity: Moderate
Ribociclib and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise tramadol exposure, increasing the risk of opioid adverse effects and seizures. Ribociclib also prolongs QT, though tramadol is not a major QT drug.
What this interaction means in plain words
Ribociclib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition by ribociclib reduces tramadol metabolism.
What to do
Monitor for sedation, respiratory depression and serotonergic effects, and lower the tramadol dose if needed. Consider an alternative analgesic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tramadol?
MediHelp rates the interaction as moderate. Ribociclib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise tramadol exposure, increasing the risk of opioid adverse effects and seizures. Ribociclib also prolongs QT, though tramadol is not a major QT drug.
How serious is the interaction between Ribociclib and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and serotonergic effects, and lower the tramadol dose if needed. Consider an alternative analgesic if toxicity develops.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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