Drug interactions
Ribociclib + Trimipramine
Severity: Major
Ribociclib and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib prolongs the QT interval in a dose-dependent way, and trimipramine also carries QT risk, so arrhythmia risk is increased. Ribociclib inhibits CYP3A4 and may raise trimipramine exposure, further increasing toxicity.
What this interaction means in plain words
Ribociclib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus ribociclib inhibition of CYP3A4-mediated metabolism.
What to do
Avoid the combination if an alternative antidepressant is possible. If used together, monitor ECG and electrolytes at baseline and regularly, and reduce trimipramine dose if adverse effects appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Trimipramine?
MediHelp rates the interaction as major. Ribociclib and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib prolongs the QT interval in a dose-dependent way, and trimipramine also carries QT risk, so arrhythmia risk is increased. Ribociclib inhibits CYP3A4 and may raise trimipramine exposure, further increasing toxicity.
How serious is the interaction between Ribociclib and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antidepressant is possible. If used together, monitor ECG and electrolytes at baseline and regularly, and reduce trimipramine dose if adverse effects appear.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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