Drug interactions
Rifabutin + Rolapitant
Severity: Moderate
Rifabutin and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may reduce rolapitant exposure. Rolapitant's efficacy may be reduced, with loss of antiemetic protection.
What this interaction means in plain words
Rifabutin and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rifabutin induces CYP3A4, increasing rolapitant metabolism.
What to do
Prefer an antiemetic not dependent on CYP3A4 exposure. If combined, monitor for breakthrough nausea and vomiting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Rolapitant?
MediHelp rates the interaction as moderate. Rifabutin and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may reduce rolapitant exposure. Rolapitant's efficacy may be reduced, with loss of antiemetic protection.
How serious is the interaction between Rifabutin and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic not dependent on CYP3A4 exposure. If combined, monitor for breakthrough nausea and vomiting.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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