Drug interactions
Rifabutin + Silodosin
Severity: Moderate
Rifabutin and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower silodosin plasma concentrations. This could reduce the effect on urinary symptoms, although rifabutin is a weaker inducer than rifampicin.
What this interaction means in plain words
Rifabutin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Silodosin belongs to Genitourinary.
Why it happens
Rifabutin induces CYP3A4 and may also induce P-glycoprotein, increasing silodosin clearance.
What to do
Monitor urinary symptom response and consider an alternative therapy if benefit is lost during rifabutin treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Silodosin?
MediHelp rates the interaction as moderate. Rifabutin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may lower silodosin plasma concentrations. This could reduce the effect on urinary symptoms, although rifabutin is a weaker inducer than rifampicin.
How serious is the interaction between Rifabutin and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and consider an alternative therapy if benefit is lost during rifabutin treatment.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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