Drug interactions
Rilonacept + Temsirolimus
Severity: Moderate
Rilonacept and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 signalling and temsirolimus suppresses T-cell proliferation through mTOR inhibition. Together they may increase the risk of serious infections.
What this interaction means in plain words
Rilonacept and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilonacept belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Additive immunosuppression through IL-1 blockade and mTOR inhibition.
What to do
Screen for active or latent infection before and during combined use, and counsel the patient to report fever or infection symptoms promptly. Interrupt one agent if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Rilonacept with Temsirolimus?
MediHelp rates the interaction as moderate. Rilonacept and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 signalling and temsirolimus suppresses T-cell proliferation through mTOR inhibition. Together they may increase the risk of serious infections.
How serious is the interaction between Rilonacept and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for active or latent infection before and during combined use, and counsel the patient to report fever or infection symptoms promptly. Interrupt one agent if a serious infection develops.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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