Drug interactions
Rilpivirine + Sevoflurane
Severity: Moderate
Rilpivirine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, but standard doses have little effect. Sevoflurane can lengthen the QT interval, so the combined risk is mainly in patients with other risk factors.
What this interaction means in plain words
Rilpivirine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilpivirine belongs to Anti Virals; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check a baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Rilpivirine with Sevoflurane?
MediHelp rates the interaction as moderate. Rilpivirine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, but standard doses have little effect. Sevoflurane can lengthen the QT interval, so the combined risk is mainly in patients with other risk factors.
How serious is the interaction between Rilpivirine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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