Drug interactions
Rilpivirine + Trimipramine
Severity: Moderate
Rilpivirine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and higher-dose rilpivirine has been associated with QT prolongation. Combined use may add to the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Rilpivirine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rilpivirine belongs to Anti Virals; Trimipramine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor QTc during combined therapy, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Rilpivirine with Trimipramine?
MediHelp rates the interaction as moderate. Rilpivirine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and higher-dose rilpivirine has been associated with QT prolongation. Combined use may add to the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Rilpivirine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during combined therapy, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc lengthens significantly.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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