Drug interactions
Risperidone + Rosiglitazone
Severity: Moderate
Risperidone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and weight gain, which may offset the benefit of rosiglitazone. Glycemic control may deteriorate.
What this interaction means in plain words
Risperidone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance opposes insulin sensitization.
What to do
Monitor glucose, HbA1c and weight, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Risperidone with Rosiglitazone?
MediHelp rates the interaction as moderate. Risperidone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and weight gain, which may offset the benefit of rosiglitazone. Glycemic control may deteriorate.
How serious is the interaction between Risperidone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, HbA1c and weight, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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