Drug interactions
Risperidone + Selinexor
Severity: Moderate
Risperidone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, fatigue and other neurological adverse effects, and risperidone can cause sedation, dizziness and orthostasis. Together they may increase the risk of impaired cognition, falls and excessive sedation.
What this interaction means in plain words
Risperidone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, counsel on fall risk and driving, and consider reducing the risperidone dose or adjusting selinexor if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Risperidone with Selinexor?
MediHelp rates the interaction as moderate. Risperidone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, fatigue and other neurological adverse effects, and risperidone can cause sedation, dizziness and orthostasis. Together they may increase the risk of impaired cognition, falls and excessive sedation.
How serious is the interaction between Risperidone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, counsel on fall risk and driving, and consider reducing the risperidone dose or adjusting selinexor if neurological toxicity develops.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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