Drug interactions
Risperidone + Sirolimus
Severity: Minor
Risperidone and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-glycoprotein and raise risperidone exposure, particularly in the brain and plasma. This could increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms. The clinical impact is expected to be modest.
What this interaction means in plain words
Risperidone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Risperidone belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Sirolimus may inhibit P-glycoprotein efflux of risperidone and its active metabolite, increasing exposure.
What to do
No routine dose change is needed; watch for sedation, hypotension and extrapyramidal symptoms after sirolimus is started. Reduce the risperidone dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Risperidone with Sirolimus?
MediHelp rates the interaction as minor. Risperidone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may inhibit P-glycoprotein and raise risperidone exposure, particularly in the brain and plasma. This could increase dose-related adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms. The clinical impact is expected to be modest.
How serious is the interaction between Risperidone and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for sedation, hypotension and extrapyramidal symptoms after sirolimus is started. Reduce the risperidone dose if adverse effects appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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