Drug interactions
Risperidone + Solifenacin
Severity: Moderate
Risperidone and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and risperidone has some anticholinergic effect that may add to that of solifenacin. Older patients may be more prone to constipation, urinary retention and confusion with this combination.
What this interaction means in plain words
Risperidone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac risk factors. Adjust therapy if the QTc lengthens or anticholinergic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Solifenacin?
MediHelp rates the interaction as moderate. Risperidone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and risperidone has some anticholinergic effect that may add to that of solifenacin. Older patients may be more prone to constipation, urinary retention and confusion with this combination.
How serious is the interaction between Risperidone and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac risk factors. Adjust therapy if the QTc lengthens or anticholinergic symptoms appear.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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