Drug interactions
Risperidone + Tacrolimus
Severity: Moderate
Risperidone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and tacrolimus may modestly increase risperidone exposure by inhibiting P-glycoprotein. Together they may raise the risk of arrhythmia and dose-related risperidone adverse effects.
What this interaction means in plain words
Risperidone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation plus possible P-glycoprotein inhibition by tacrolimus reducing risperidone efflux.
What to do
Monitor ECG and electrolytes, especially magnesium and potassium, which tacrolimus can lower. Watch for sedation and extrapyramidal symptoms and reduce the risperidone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Risperidone with Tacrolimus?
MediHelp rates the interaction as moderate. Risperidone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and tacrolimus may modestly increase risperidone exposure by inhibiting P-glycoprotein. Together they may raise the risk of arrhythmia and dose-related risperidone adverse effects.
How serious is the interaction between Risperidone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, especially magnesium and potassium, which tacrolimus can lower. Watch for sedation and extrapyramidal symptoms and reduce the risperidone dose if needed.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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