Drug interactions
Risperidone + Tipranavir
Severity: Moderate
Risperidone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which is a potent CYP3A4 and CYP2D6 inhibitor and also affects P-glycoprotein. Risperidone exposure may therefore rise, increasing sedation, hypotension and extrapyramidal effects.
What this interaction means in plain words
Risperidone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 and CYP3A4 (largely via coadministered ritonavir) reducing risperidone clearance.
What to do
Start risperidone at a lower dose and titrate slowly. Monitor for extrapyramidal symptoms, sedation and QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Risperidone with Tipranavir?
MediHelp rates the interaction as moderate. Risperidone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is given with ritonavir, which is a potent CYP3A4 and CYP2D6 inhibitor and also affects P-glycoprotein. Risperidone exposure may therefore rise, increasing sedation, hypotension and extrapyramidal effects.
How serious is the interaction between Risperidone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start risperidone at a lower dose and titrate slowly. Monitor for extrapyramidal symptoms, sedation and QT effects.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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