Drug interactions
Rivaroxaban + Rucaparib
Severity: Minor
Rivaroxaban and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may slightly raise rivaroxaban exposure. This could modestly increase bleeding risk, particularly in patients with other risk factors such as renal impairment or thrombocytopenia from PARP inhibition.
What this interaction means in plain words
Rivaroxaban and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rivaroxaban belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, reducing rivaroxaban clearance.
What to do
Monitor for bleeding and check blood counts regularly, since rucaparib can cause cytopenias. No empirical dose reduction is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rivaroxaban with Rucaparib?
MediHelp rates the interaction as minor. Rivaroxaban and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may slightly raise rivaroxaban exposure. This could modestly increase bleeding risk, particularly in patients with other risk factors such as renal impairment or thrombocytopenia from PARP inhibition.
How serious is the interaction between Rivaroxaban and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check blood counts regularly, since rucaparib can cause cytopenias. No empirical dose reduction is usually required.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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