Drug interactions
Rivaroxaban + Stiripentol
Severity: Moderate
Rivaroxaban and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so rivaroxaban exposure could rise or fall unpredictably. Either outcome matters, as higher exposure raises bleeding risk and lower exposure reduces antithrombotic protection.
What this interaction means in plain words
Rivaroxaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rivaroxaban belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol mixed CYP3A4 inhibition and induction (with possible P-gp effects) alters rivaroxaban clearance.
What to do
Monitor for bleeding and for thromboembolic events after starting or stopping stiripentol. Consider an alternative anticoagulant if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Rivaroxaban with Stiripentol?
MediHelp rates the interaction as moderate. Rivaroxaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so rivaroxaban exposure could rise or fall unpredictably. Either outcome matters, as higher exposure raises bleeding risk and lower exposure reduces antithrombotic protection.
How serious is the interaction between Rivaroxaban and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and for thromboembolic events after starting or stopping stiripentol. Consider an alternative anticoagulant if control is unstable.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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