Drug interactions
Roflumilast + Tucatinib
Severity: Moderate
Roflumilast and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase roflumilast exposure, increasing the likelihood of gastrointestinal, weight and psychiatric adverse effects.
What this interaction means in plain words
Roflumilast and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roflumilast belongs to Respiratory; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, decreasing roflumilast clearance.
What to do
Monitor for roflumilast adverse effects and weight loss, and consider holding roflumilast if intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Roflumilast with Tucatinib?
MediHelp rates the interaction as moderate. Roflumilast and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase roflumilast exposure, increasing the likelihood of gastrointestinal, weight and psychiatric adverse effects.
How serious is the interaction between Roflumilast and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects and weight loss, and consider holding roflumilast if intolerance develops.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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