Drug interactions
Rolapitant + Timolol
Severity: Moderate
Rolapitant and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol is partly cleared by CYP2D6, and rolapitant inhibits this enzyme for weeks. Increased timolol exposure may cause bradycardia, hypotension, or bronchospasm, including with ophthalmic use.
What this interaction means in plain words
Rolapitant and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Timolol belongs to Cardiovascular.
Why it happens
Rolapitant inhibits CYP2D6-mediated metabolism of timolol.
What to do
Monitor heart rate and blood pressure, and for respiratory symptoms. Reduce the timolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Rolapitant with Timolol?
MediHelp rates the interaction as moderate. Rolapitant and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol is partly cleared by CYP2D6, and rolapitant inhibits this enzyme for weeks. Increased timolol exposure may cause bradycardia, hypotension, or bronchospasm, including with ophthalmic use.
How serious is the interaction between Rolapitant and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and for respiratory symptoms. Reduce the timolol dose if bradycardia or hypotension develops.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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