Drug interactions
Rolapitant + Tolterodine
Severity: Moderate
Rolapitant and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolterodine is metabolized by CYP2D6 to an active metabolite, and rolapitant inhibits this enzyme for a prolonged time. Parent drug exposure may rise, increasing anticholinergic effects and possibly QT effects.
What this interaction means in plain words
Rolapitant and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Tolterodine belongs to Genitourinary.
Why it happens
Rolapitant inhibits CYP2D6, reducing tolterodine clearance.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation, and urinary retention. Consider a lower tolterodine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Tolterodine
Frequently asked questions
Can I take Rolapitant with Tolterodine?
MediHelp rates the interaction as moderate. Rolapitant and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolterodine is metabolized by CYP2D6 to an active metabolite, and rolapitant inhibits this enzyme for a prolonged time. Parent drug exposure may rise, increasing anticholinergic effects and possibly QT effects.
How serious is the interaction between Rolapitant and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation, and urinary retention. Consider a lower tolterodine dose if they occur.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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