Drug interactions
Rosiglitazone + Stiripentol
Severity: Moderate
Rosiglitazone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes, including CYP2C8, which is the main pathway for rosiglitazone clearance. Rosiglitazone exposure may rise, increasing the risk of fluid retention, edema, weight gain and hypoglycemia.
What this interaction means in plain words
Rosiglitazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8-mediated rosiglitazone metabolism by stiripentol.
What to do
Monitor blood glucose and signs of fluid retention or heart failure when the combination is started. Reduce the rosiglitazone dose if adverse effects or hypoglycemia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Rosiglitazone with Stiripentol?
MediHelp rates the interaction as moderate. Rosiglitazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes, including CYP2C8, which is the main pathway for rosiglitazone clearance. Rosiglitazone exposure may rise, increasing the risk of fluid retention, edema, weight gain and hypoglycemia.
How serious is the interaction between Rosiglitazone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of fluid retention or heart failure when the combination is started. Reduce the rosiglitazone dose if adverse effects or hypoglycemia occur.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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