Drug interactions
Rosuvastatin + Stiripentol
Severity: Moderate
Rosuvastatin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits BCRP in vitro and may increase rosuvastatin exposure. The clinical effect is not well characterised but could increase muscle toxicity.
What this interaction means in plain words
Rosuvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of BCRP-mediated efflux increases rosuvastatin absorption.
What to do
Monitor for muscle symptoms and reduce the rosuvastatin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Stiripentol
Frequently asked questions
Can I take Rosuvastatin with Stiripentol?
MediHelp rates the interaction as moderate. Rosuvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits BCRP in vitro and may increase rosuvastatin exposure. The clinical effect is not well characterised but could increase muscle toxicity.
How serious is the interaction between Rosuvastatin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and reduce the rosuvastatin dose if adverse effects occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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