Drug interactions
Rosuvastatin + Vadadustat
Severity: Moderate
Rosuvastatin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and raises rosuvastatin exposure, increasing the risk of statin-related muscle toxicity.
What this interaction means in plain words
Rosuvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
BCRP inhibition by vadadustat increases rosuvastatin absorption and reduces efflux.
What to do
Do not exceed rosuvastatin 5 mg daily with vadadustat and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Rosuvastatin with Vadadustat?
MediHelp rates the interaction as moderate. Rosuvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and raises rosuvastatin exposure, increasing the risk of statin-related muscle toxicity.
How serious is the interaction between Rosuvastatin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed rosuvastatin 5 mg daily with vadadustat and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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