Drug interactions
Rosuvastatin + Vorasidenib
Severity: Moderate
Rosuvastatin and Vorasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorasidenib may inhibit BCRP and increase rosuvastatin exposure. This could raise the risk of statin-related muscle toxicity.
What this interaction means in plain words
Rosuvastatin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Vorasidenib belongs to Oncology.
Why it happens
Inhibition of intestinal BCRP efflux, increasing rosuvastatin absorption.
What to do
Monitor for myalgia and consider checking creatine kinase if symptoms occur. Use the lowest effective rosuvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vorasidenib
- Ciprofloxacin + Vorasidenib Major
- Fluvoxamine + Vorasidenib Major
- Tacrolimus + Vorasidenib Major
- Vorasidenib + Warfarin Major
- Midazolam + Vorasidenib Moderate
- Phenytoin + Vorasidenib Moderate
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Vorasidenib?
MediHelp rates the interaction as moderate. Rosuvastatin and Vorasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorasidenib may inhibit BCRP and increase rosuvastatin exposure. This could raise the risk of statin-related muscle toxicity.
How serious is the interaction between Rosuvastatin and Vorasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider checking creatine kinase if symptoms occur. Use the lowest effective rosuvastatin dose.
What other medicines interact with Vorasidenib?
MediHelp also lists interactions of Vorasidenib with, for example, Ciprofloxacin, Fluvoxamine, Tacrolimus. The full list is on the Vorasidenib page.
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