Drug interactions
Rucaparib + Tacrolimus
Severity: Moderate
Rucaparib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly increase tacrolimus concentrations. This can heighten the risk of tacrolimus toxicity, especially in patients with narrow margins.
What this interaction means in plain words
Rucaparib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated tacrolimus metabolism by rucaparib.
What to do
Monitor tacrolimus trough levels and renal function when rucaparib is started or stopped. Lower the tacrolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tacrolimus?
MediHelp rates the interaction as moderate. Rucaparib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly increase tacrolimus concentrations. This can heighten the risk of tacrolimus toxicity, especially in patients with narrow margins.
How serious is the interaction between Rucaparib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when rucaparib is started or stopped. Lower the tacrolimus dose if levels rise.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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