Drug interactions
Rucaparib + Tizanidine
Severity: Moderate
Rucaparib and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP1A2 inhibitor and tizanidine depends heavily on CYP1A2 for clearance. Higher tizanidine exposure may produce excessive hypotension, drowsiness and bradycardia.
What this interaction means in plain words
Rucaparib and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tizanidine belongs to Musculoskeletal.
Why it happens
Rucaparib inhibits CYP1A2, reducing first-pass and systemic metabolism of tizanidine.
What to do
Monitor blood pressure and sedation and lower the tizanidine dose if needed. Consider an alternative antispasticity agent if the combination is poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tizanidine?
MediHelp rates the interaction as moderate. Rucaparib and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP1A2 inhibitor and tizanidine depends heavily on CYP1A2 for clearance. Higher tizanidine exposure may produce excessive hypotension, drowsiness and bradycardia.
How serious is the interaction between Rucaparib and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation and lower the tizanidine dose if needed. Consider an alternative antispasticity agent if the combination is poorly tolerated.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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