Drug interactions
Rucaparib + Torsemide
Severity: Minor
Rucaparib and Torsemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9, which metabolizes torsemide. Torsemide exposure may increase moderately, enhancing diuresis and the risk of volume depletion and electrolyte loss.
What this interaction means in plain words
Rucaparib and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Torsemide belongs to Cardiovascular.
Why it happens
Rucaparib inhibits CYP2C9-mediated metabolism of torsemide.
What to do
Monitor volume status, blood pressure and electrolytes, and reduce the torsemide dose if exaggerated diuresis occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Torsemide
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Torsemide?
MediHelp rates the interaction as minor. Rucaparib and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C9, which metabolizes torsemide. Torsemide exposure may increase moderately, enhancing diuresis and the risk of volume depletion and electrolyte loss.
How serious is the interaction between Rucaparib and Torsemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure and electrolytes, and reduce the torsemide dose if exaggerated diuresis occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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