Drug interactions
Rucaparib + Voriconazole
Severity: Minor
Rucaparib and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2 and to a lesser extent CYP2C19, CYP2C9 and CYP3A4, which could modestly raise voriconazole concentrations. Clinical significance is likely small but adverse effects such as visual disturbance or hepatotoxicity could increase.
What this interaction means in plain words
Rucaparib and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Weak to moderate inhibition of CYP2C19, CYP2C9 and CYP3A4 by rucaparib may reduce voriconazole metabolism.
What to do
No routine dose change is needed; monitor for voriconazole adverse effects and liver tests, and check trough levels if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Voriconazole?
MediHelp rates the interaction as minor. Rucaparib and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2 and to a lesser extent CYP2C19, CYP2C9 and CYP3A4, which could modestly raise voriconazole concentrations. Clinical significance is likely small but adverse effects such as visual disturbance or hepatotoxicity could increase.
How serious is the interaction between Rucaparib and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for voriconazole adverse effects and liver tests, and check trough levels if toxicity is suspected.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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