Drug interactions
Ruxolitinib + Tazemetostat
Severity: Minor
Ruxolitinib and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may modestly lower ruxolitinib exposure. Clinical significance is likely small but loss of efficacy is possible.
What this interaction means in plain words
Ruxolitinib and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ruxolitinib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4, slightly increasing ruxolitinib metabolism.
What to do
Monitor response to ruxolitinib; no routine dose change is needed unless efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ruxolitinib with Tazemetostat?
MediHelp rates the interaction as minor. Ruxolitinib and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may modestly lower ruxolitinib exposure. Clinical significance is likely small but loss of efficacy is possible.
How serious is the interaction between Ruxolitinib and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to ruxolitinib; no routine dose change is needed unless efficacy declines.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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