Drug interactions
Ruxolitinib + Trastuzumab deruxtecan
Severity: Moderate
Ruxolitinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression and immune impairment, so combining them may increase neutropenia and infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Ruxolitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ruxolitinib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive pharmacodynamic effects.
What to do
Monitor complete blood counts regularly and watch for infection; hold or reduce doses per labeling for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Ruxolitinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Ruxolitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression and immune impairment, so combining them may increase neutropenia and infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Ruxolitinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for infection; hold or reduce doses per labeling for neutropenia.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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