Drug interactions
Ruxolitinib + Voriconazole
Severity: Moderate
Ruxolitinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases ruxolitinib exposure, which may worsen thrombocytopenia, neutropenia and anemia.
What this interaction means in plain words
Ruxolitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ruxolitinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of ruxolitinib.
What to do
Reduce the ruxolitinib dose per labeling during voriconazole use and monitor blood counts frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ruxolitinib with Voriconazole?
MediHelp rates the interaction as moderate. Ruxolitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases ruxolitinib exposure, which may worsen thrombocytopenia, neutropenia and anemia.
How serious is the interaction between Ruxolitinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling during voriconazole use and monitor blood counts frequently.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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