Drug interactions
Saxagliptin + Stiripentol
Severity: Minor
Saxagliptin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and may also induce CYP3A4 and can affect P-glycoprotein, so saxagliptin exposure could change in either direction. The net effect on saxagliptin and its active metabolite is not well characterized.
What this interaction means in plain words
Saxagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction and possible P-gp inhibition by stiripentol, with the net effect on saxagliptin not established.
What to do
Monitor glycemic response and adverse effects when stiripentol is started or stopped. Limit saxagliptin to 2.5 mg daily if clear signs of increased exposure appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Saxagliptin with Stiripentol?
MediHelp rates the interaction as minor. Saxagliptin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and may also induce CYP3A4 and can affect P-glycoprotein, so saxagliptin exposure could change in either direction. The net effect on saxagliptin and its active metabolite is not well characterized.
How serious is the interaction between Saxagliptin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and adverse effects when stiripentol is started or stopped. Limit saxagliptin to 2.5 mg daily if clear signs of increased exposure appear.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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