Drug interactions
Secobarbital + Tucatinib
Severity: Major
Secobarbital and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and CYP2C8, enzymes that contribute to tucatinib metabolism, and thereby lower its concentrations. Reduced exposure may weaken efficacy in HER2-positive breast cancer.
What this interaction means in plain words
Secobarbital and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Secobarbital belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 and CYP2C8 increases tucatinib clearance.
What to do
Avoid strong CYP3A4 or CYP2C8 inducers with tucatinib and use an alternative sedative. Monitor for reduced response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Secobarbital with Tucatinib?
MediHelp rates the interaction as major. Secobarbital and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may induce CYP3A4 and CYP2C8, enzymes that contribute to tucatinib metabolism, and thereby lower its concentrations. Reduced exposure may weaken efficacy in HER2-positive breast cancer.
How serious is the interaction between Secobarbital and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 or CYP2C8 inducers with tucatinib and use an alternative sedative. Monitor for reduced response if unavoidable.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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