Drug interactions
Selexipag + Teriflunomide
Severity: Moderate
Selexipag and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is metabolized to its active metabolite partly via CYP2C8, and teriflunomide inhibits CYP2C8. Exposure to selexipag may rise, increasing adverse effects such as headache, diarrhea and hypotension.
What this interaction means in plain words
Selexipag and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selexipag belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8-mediated metabolism of selexipag.
What to do
Reduce selexipag to once-daily dosing if coadministered with a moderate CYP2C8 inhibitor, and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Selexipag with Teriflunomide?
MediHelp rates the interaction as moderate. Selexipag and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is metabolized to its active metabolite partly via CYP2C8, and teriflunomide inhibits CYP2C8. Exposure to selexipag may rise, increasing adverse effects such as headache, diarrhea and hypotension.
How serious is the interaction between Selexipag and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce selexipag to once-daily dosing if coadministered with a moderate CYP2C8 inhibitor, and monitor tolerability.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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