Drug interactions
Selinexor + Tramadol
Severity: Moderate
Selinexor and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue. Tramadol can cause dizziness, sedation and seizures, so combined use may worsen neurological and cognitive effects and increase fall risk.
What this interaction means in plain words
Selinexor and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients about falls and driving. Consider dose reduction of tramadol or a different analgesic if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Tramadol?
MediHelp rates the interaction as moderate. Selinexor and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue. Tramadol can cause dizziness, sedation and seizures, so combined use may worsen neurological and cognitive effects and increase fall risk.
How serious is the interaction between Selinexor and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients about falls and driving. Consider dose reduction of tramadol or a different analgesic if neurological symptoms develop.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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