Drug interactions
Selinexor + Trimipramine
Severity: Moderate
Selinexor and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and trimipramine is sedating and anticholinergic. Together they may add to cognitive impairment, sedation and fall risk, particularly in older patients.
What this interaction means in plain words
Selinexor and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients on fall risk. Consider reducing the trimipramine dose or choosing a less sedating alternative if neurological toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Trimipramine?
MediHelp rates the interaction as moderate. Selinexor and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and trimipramine is sedating and anticholinergic. Together they may add to cognitive impairment, sedation and fall risk, particularly in older patients.
How serious is the interaction between Selinexor and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients on fall risk. Consider reducing the trimipramine dose or choosing a less sedating alternative if neurological toxicity develops.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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