Drug interactions
Sevoflurane + Tacrolimus
Severity: Moderate
Sevoflurane and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, particularly at high levels or with hypomagnesemia, and sevoflurane has similar effects. The combination may increase arrhythmia risk perioperatively.
What this interaction means in plain words
Sevoflurane and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation; tacrolimus-related hypomagnesemia and hyperkalemia may contribute.
What to do
Check baseline ECG, magnesium, potassium and tacrolimus trough before surgery. Continue tacrolimus as advised by the transplant team and monitor the ECG intraoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sevoflurane with Tacrolimus?
MediHelp rates the interaction as moderate. Sevoflurane and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, particularly at high levels or with hypomagnesemia, and sevoflurane has similar effects. The combination may increase arrhythmia risk perioperatively.
How serious is the interaction between Sevoflurane and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, magnesium, potassium and tacrolimus trough before surgery. Continue tacrolimus as advised by the transplant team and monitor the ECG intraoperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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