Drug interactions
Sevoflurane + Temazepam
Severity: Moderate
Sevoflurane and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines such as temazepam add to the central nervous system depressant effect of sevoflurane. This can deepen sedation, lower the anesthetic requirement, and increase the risk of hypotension and respiratory depression.
What this interaction means in plain words
Sevoflurane and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through enhancement of GABA-A receptor activity by both agents.
What to do
Titrate sevoflurane concentration to clinical effect and anesthetic depth monitoring, expecting a lower requirement in patients taking temazepam. Monitor ventilation and blood pressure perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sevoflurane and Temazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sevoflurane
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Sevoflurane with Temazepam?
MediHelp rates the interaction as moderate. Sevoflurane and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines such as temazepam add to the central nervous system depressant effect of sevoflurane. This can deepen sedation, lower the anesthetic requirement, and increase the risk of hypotension and respiratory depression.
How serious is the interaction between Sevoflurane and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane concentration to clinical effect and anesthetic depth monitoring, expecting a lower requirement in patients taking temazepam. Monitor ventilation and blood pressure perioperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
