Drug interactions
Sevoflurane + Voriconazole
Severity: Moderate
Sevoflurane and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined perioperative use may increase the risk of ventricular arrhythmias. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Sevoflurane and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Correct potassium and magnesium before surgery and monitor ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Voriconazole?
MediHelp rates the interaction as moderate. Sevoflurane and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined perioperative use may increase the risk of ventricular arrhythmias. Risk is higher with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Sevoflurane and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before surgery and monitor ECG during anesthesia.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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