Drug interactions
Sevoflurane + Vorinostat
Severity: Moderate
Sevoflurane and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and sevoflurane can also lengthen repolarization. Using both may increase the chance of torsades de pointes, especially with low potassium or magnesium.
What this interaction means in plain words
Sevoflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Correct electrolytes and obtain a baseline ECG before anesthesia. Monitor the ECG intraoperatively and avoid other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Sevoflurane with Vorinostat?
MediHelp rates the interaction as moderate. Sevoflurane and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and sevoflurane can also lengthen repolarization. Using both may increase the chance of torsades de pointes, especially with low potassium or magnesium.
How serious is the interaction between Sevoflurane and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes and obtain a baseline ECG before anesthesia. Monitor the ECG intraoperatively and avoid other QT-prolonging agents.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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