Drug interactions
Silodosin + Tadalafil
Severity: Moderate
Silodosin and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and combining a PDE5 inhibitor with an alpha-1 blocker can cause symptomatic orthostatic hypotension. Silodosin is uroselective but the risk is still present.
What this interaction means in plain words
Silodosin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Silodosin belongs to Genitourinary; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 adrenergic blockade and PDE5 inhibition.
What to do
Ensure the patient is stable on the alpha-blocker before adding tadalafil, starting with the lowest dose. Monitor for orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Silodosin with Tadalafil?
MediHelp rates the interaction as moderate. Silodosin and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and combining a PDE5 inhibitor with an alpha-1 blocker can cause symptomatic orthostatic hypotension. Silodosin is uroselective but the risk is still present.
How serious is the interaction between Silodosin and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure the patient is stable on the alpha-blocker before adding tadalafil, starting with the lowest dose. Monitor for orthostatic symptoms.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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