Drug interactions
Silodosin + Terazosin
Severity: Major
Silodosin and Terazosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block alpha-1 adrenoceptors, so combined use duplicates therapy and raises the risk of orthostatic hypotension, dizziness and syncope with no added benefit.
What this interaction means in plain words
Silodosin and Terazosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Silodosin belongs to Genitourinary; Terazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic receptor blockade causing vasodilation.
What to do
Avoid using two alpha-1 blockers together; choose one agent. If switching, stop the first drug and begin the second at a low starting dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Silodosin with Terazosin?
MediHelp rates the interaction as major. Silodosin and Terazosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block alpha-1 adrenoceptors, so combined use duplicates therapy and raises the risk of orthostatic hypotension, dizziness and syncope with no added benefit.
How serious is the interaction between Silodosin and Terazosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two alpha-1 blockers together; choose one agent. If switching, stop the first drug and begin the second at a low starting dose.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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