Drug interactions
Silodosin + Timolol
Severity: Minor
Silodosin and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral timolol is a beta-blocker that may add to the hypotensive effect of silodosin. Ophthalmic timolol has limited systemic exposure but can occasionally contribute in susceptible patients.
What this interaction means in plain words
Silodosin and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Silodosin belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and beta-adrenergic blockade.
What to do
Monitor standing blood pressure and counsel on slow posture changes, particularly with oral timolol. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Silodosin with Timolol?
MediHelp rates the interaction as minor. Silodosin and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral timolol is a beta-blocker that may add to the hypotensive effect of silodosin. Ophthalmic timolol has limited systemic exposure but can occasionally contribute in susceptible patients.
How serious is the interaction between Silodosin and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing blood pressure and counsel on slow posture changes, particularly with oral timolol. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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