Drug interactions
Silodosin + Tolvaptan
Severity: Minor
Silodosin and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and may raise silodosin exposure, since silodosin is a P-gp substrate. Higher silodosin levels could increase dizziness, orthostatic hypotension and other adverse effects.
What this interaction means in plain words
Silodosin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Silodosin belongs to Genitourinary; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan inhibits P-glycoprotein efflux, potentially reducing silodosin efflux and increasing its absorption.
What to do
Monitor for orthostatic symptoms when starting or stopping tolvaptan in a patient on silodosin. Reduce silodosin dose only if hypotension or dizziness develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Silodosin with Tolvaptan?
MediHelp rates the interaction as minor. Silodosin and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and may raise silodosin exposure, since silodosin is a P-gp substrate. Higher silodosin levels could increase dizziness, orthostatic hypotension and other adverse effects.
How serious is the interaction between Silodosin and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic symptoms when starting or stopping tolvaptan in a patient on silodosin. Reduce silodosin dose only if hypotension or dizziness develops.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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